Program

09:30 - 10:40

Session 1 - Unraveling the SASP I 

09:30-09:50 Bill Keyes (IGBMC) - Senescence as a Conserved Biological Program in Development, Aging, and Disease
09:50-10:10 Ana O’Loghlen (Spanish National Research Council (CSIC)) - “Resolvin” inflammation in senescence and ageing
10:10-10:20 Laura Gonzalez-Trueba (National University of Singapore) - Senescent cell-derived extracellular vesicles distinctly impede tumor recurrence by antitumor immune response and function
10:20-10:30  Alejandro Failde-Fiestras (Center for Research in Molecular Medicine (CiMUS), University of Santiago de Compostela) - Apoptotic Secreted Factors as Drivers of Apoptosis-Induced Senescence (AIS)
10:30-10:40  Serena Vegna (The Netherlands Cancer Institute) - Niche-Specific Remodeling of Senescent Tumor Cells and Macrophages Underlies Resistance to Pro-Senescence Therapy in Liver Cancer

10:40 - 11:20

coffee break

11:20 - 12:40

Session 2 - Viral induced senescence: 
Sponsored by the University of Eastern Piedmont (UPO)

11:20-11:40 François Trottein (Institut Pasteur de Lille) - Ageing, cellular senescence and respiratory viral infections
11:40-11:55 Clemens Schmitt (Johannes Kepler University) - Targeting the senescence-disabling serine synthesis pathway eliminates chemotherapy surviving cancer cell persisters
11:55-12:10 Stefanie Deinhardt-Emmer (Jena University Hospital) - Virus-Induced Cellular Senescence Drives Pathogenesis and Long-Term Consequences in Influenza and SARS-CoV-2 Infection
12:10-12:25 Marco De Andrea (University of Eastern Piedmont) - HCMV Induces Senescence and Paracrine Inflammation in Human Endothelial Cells
12:25-12:40 Federico Armando (University of Parma and University of Veterinary Medicine Foundation, Hanover) - Viral induced senescence of alveolar progenitors and respiratory long-COVID

12:40 - 13:10

Flash talks I selected from abstracts (8 x 3 min)

1. Marco Malavolta (Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS) - Senolytic Strategies as Therapeutic Approaches for Frailty in Aging Mice
2. Laura Sinclair (University of Exeter) - Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones
3. Daniel Muñoz-Espin (University of Cambridge) - Ageing promotes a senescent protumorigenic niche in lung cancer
4. Vidyani Suryadevara (Stanford University) - Identification of senescence in human osteoarthritis talus joints using novel imaging approaches
5. Mengling Huang (European Research Institute for the Biology of Ageing (ERIBA)) - Inhibition of Purinergic Signaling Suppresses the SASP and Ameliorates Aging and Disease Phenotypes
6.Amrita Nepalia (Indian Institute of Science Bangalore) - Age-Associated Downregulation of a Mitochondrial Import Protein Drives Senescence and Mitochondrial Dysfunction
7. Kamila Kozik (Okinawa Institute of Science and Technology) - Constitutive Macropinocytosis Is a Hallmark of Senescent Cells and Is Regulated by PAK1
8. Pamela Martinez-Orellana (The International Centre for Genetic Engineering and Biotechnology (ICGEB)) - Virus-induced senescence is correlated to DNA damage and loss of neuronal networks mediated by the pro-inflammatory activation of the cGAS-STING pathway

13:10 - 15:00

Lunch + Poster Session 1 (even-numbered posters)

15:00 - 16:40

Session 3 - Senescence as a player in myriad diseases

15:00-15:20 Marco Demaria (ERIBA) - TSPAN13 Orchestrates Senescence and Aging Through Integrin Signaling
15:20-15:40 Anna Picca (Università LUM Giuseppe Degennaro) - Mitochondria-Derived Vesicles in Aging and Associated Conditions
15:40-16:00 Marielle Saclier (CNRS UMR3738, Paris) - Deciphering the Senescent Cell and Macrophage Dialogue in Muscle Regeneration
16:00-16:10 Yara El Masri (UMR CNRS 6015 INSERM) - The Role of Senescence in Complex I Mitochondrial Diseases - ICSA Travel Award Winner   
16:10-16:20 Edoardo Scarpa (Università Degli Studi di Milano) - Targeting Infection-Induced Senescence to Eradicate Persistent Mycobacteria
16:20-16:30 Samir Morsli (Karolinska Institutet) - Identifying targetable features of senescence escape following cancer therapy
16:30-16:40 Manuel Collado (CIMUS-USC, Santiago de Compostela) - Senomorphic activity of partial reprogramming

16:40 - 17:40

Keynote Speaker: Laura Niedernhofer

18:15 - 20:30

Welcome Reception (off-site at La Limonaia, approx. 20 min walking)

09:00 - 10:40

Session 4 - Cellular mechanisms associated with senescence: from Metabolism, to Immunity, and Mitochondria

09:00-09:20 Eugenio Barone - From insulin signaling to mitochondrial fitness: metabolic pathways shaping brain aging
09:20-09:40 Masashi Narita (Cancer Research UK Cambridge Institute University of Cambridge) - Cellular functionality and plasticity in the senescence spectrum yICSA Speaker
09:40-10:00 Maria Mittelbrunn (Centro de Biologia Molecular, CSIC-UAM) - Immunosenescence as the Central Mediator of Age-Related Vulnerability
10:00-10:10 Nicolas Malaquin (Institut du cancer de Montréal) - From DNA damage to inflammatory output: Unraveling the multistep process leading to senescence and SASP establishment
10:10-10:20  Yeonghyeon Lee (Seoul National University) - Autophagy-dependent splicing control directs translation toward inflammation during senescence
10:20-10:30  Utz Herbig (Rutgers-New Jersey Medical School) - Senescent SA-βGal expressing CD8+ T Cells are Functionally Impaired and Enriched in Disease
10:30-10:40  Valentin L'Hôte (Umeå University) - Mitochondrial replisome alterations in senescence trigger mtDNA cytosolic release to promote a specific subset of the SASP

10:40 - 11:20

coffee break

11:20 - 12:30

Session 5 - Senescence and cancer

11:20-11:40 Valery Krizhanovsky (EKARD Institute for Cancer Diagnosis Research) - Senescent cells on the crossroads of cancer and aging
11:40-12:00 Raffaella DiMicco - yICSA Speaker
12:00-12:10 Alexandra Guelton (University of Lorraine) - Characterization of Mesenchymal Stromal Cell (MSC) Senescence During Acute Myeloid Leukemia (AML) Treatment with Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT)
12:10-12:20 András Furedi (Institute of Molecular Life Sciences, Center of Excellence of The Hungarian Academy of Sciences) - Therapy-induced senescence is a transient drug resistance mechanism in breast cancer
12:20-12:30 Juliana I. Delgado (Memorial Sloan Kettering Cancer Center) - A tale of two drugs: exploring differential outcomes of CDK4/6i senescence and implications for therapy

12:30 - 13:00

Flash talks II selected from abstracts (7 x 3 min)

1. Andrea Rodríguez-Agustín(Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomédiques August Pi i Sunyer (FRCB-IDIBAPS)) - HIV Tat protein-induced DNA methylation alterations as an epigenetic dysregulation underlying accelerated aging in people with HIV (PWH)
2. Ignacio Benedicto (Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC)) - Senescence alters stretch-induced mechanotransduction in endothelial cells
3. Maria Pilar Picallos-Rabina (Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela) - A nutraceutical strategy against senescence by using oleic acid
4. Simona Fusco (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)) - Therapy-Induced Senescence Promotes Immunogenicity in Acute Myeloid Leukemia Blasts through loss of PRC2-Mediated Regulation
5. Julien Cherfils-Vicini (IRCAN – Institute for the Research on Aging & Cancer) - Senescence associated Immune Checkpoint (SIC) Targeting: Long-Term Immunotherapy for Age-Related Disease Prevention
6. Alessio Piccolantonio (European Research Institute for the Biology of Ageing (ERIBA)) - Investigating the Role of Cellular Senescence in Systemic Sclerosis
7. Markus Schosserer (Medical University of Vienna) - Exploring ribosomal RNA modifications and corresponding snoRNAs in human skin cell senescence

13:00 - 15:00

Lunch + Poster Session 2 (odd-numbered posters)

15:00 - 16:50

Session 6 - Senescence in aging pathologies

15:00-15:20 Keiko Kono (OIST) - Plasma Membrane Damage Triggers Cellular Senescence, Linking Mechanical Stress to Age-related Pathologies
15:20-15:40 Fabrizio d’Adda di Fagagna (IFOM) - Telomere biology in aging and age-related diseases: mechanisms and therapies
15:40-16:00 Sofia Ferreira (Institute for Regeneration and Repair, University of Edinburgh) - Cellular senescence: the ‘Achilles heel’’ of liver transplantation
16:00-16:10 Zinnarky K. Ortiz Correa (Mayo Clinic Graduate School of Biomedical Sciences) - Inflammation and Senescence in Adipose Tissue as Potential Contributors to Skeletal Muscle Dysfunction in Older Adults                 
16:10-16:20 Osama Elsallabi (University "G. d'Annunzio" of Chieti-Pescara) - Inhibiting SMAD3 Attenuates Senescence in Aging Mouse Models
16:20-16:30 Yacine Djabali (Mondor Institute for Biomedical Research) - Deconstructing Biological Age in Elderly Lung Cancer Patients Reveals Cellular Senescence as a Dominant Driver of Frailty
16:30-16:40 Alessandra Pierantoni (Institute for Research on Cancer and Aging of Nice (IRCAN)) - Intergenerational Impact of p16 Activation in Oocytes on Immune Function and Cancer Susceptibility
16:40-16:50 Sebastian Igelmann (VIB Center for Cancer Biology) - Age-accumulated senescent cells fuel melanoma metastasis growth via NK cell inhibition

17:00 - 18:00

yICSA Event (limited to early career researchers) - Feat. Rafaella Di Micco & Masashi Narita

20:00

Gala Dinner & Party – Baja Roma

09:30 - 11:10

Session 7 - Senescence pathways: From mechanism to therapeutic opportunity

09:30-09:40 Elia Cappuccio (University of Innsbruck) - Loss of FAHD1 mediates mitochondrial dysfunction: implications for cellular senescence
09:40-09:50 Núria Climent (Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS)) - Senolytic Treatment with Dasatinib and Quercetin Reduces Cellular Senescence Biomarkers in People Living with HIV
09:50-10:10 Dmitry Bulavin (IRCAN) - A Role for p16High Immune Cells in Disease Tolerance as a Crucial Defense Strategy
10:10-10:30 Chanhee Khang (Seoul National University) - Multi-layered regulation of the senescence-associated secretory phenotype
10:30-10:40 Tornike Nasrashvili (Leibniz-Institute on Aging - Fritz-Lipmann-Institute e.V.) - Analysis of PTMs in secretory pathways of senescent human cells
10:40-10:50 Panagiotis Galanos (University of Southern Denmark) - Hijacking senescence: how cancer cells exploit replication stress to escape
10:50-11:00 Suramya Asthana (Indian Institute of Science) - Dysregulated cholesterol homeostasis drives signalling changes in senescent cells and presents a novel target for senotherapy
11:00-11:10 Rahul S. Samant (Babraham Institute) - Divergent proteostasis strategies underpin misfolded protein trafficking in senescent cellular states

11:10 - 11:50

coffee break

11:50 - 12:50

General assembly, closure and poster prizes

12:50 - 14:00

Lunch

15:00 - 17:00

Optional guided tour of the historic City Center